Clinical beta
FMBM is currently in clinical beta. Content is for professional review/testing and must not replace local protocols, senior clinical judgment, or official prescribing references.
Drug Monograph
USE IF: Vitamin B12 deficiency, megaloblastic anemia, neurologic symptoms due to deficiency
AVOID IF: Known hypersensitivity (rare)
Vitamin B12 (Cyanocobalamin)
Vitamin B12 replacement for hematologic and neurologic deficiency states
Indication
Vitamin B12 deficiency • Megaloblastic anemia • Neurologic deficiency states
INDICATIONS (CORE USE)
- Vitamin B12 deficiency - Megaloblastic anemia - Neurologic manifestations due to deficiency (e.g., neuropathy)
ADULT DOSE (STANDARD)
IM loading regimen followed by maintenance; oral therapy possible in selected patients
MAX DOSE
Not typically dose-limited in deficiency correction
Route
IM • PO
PEDIATRIC DOSE
Protocol-based
Must-not-miss safety points
Major warning
- Untreated B12 deficiency can cause irreversible neurologic damage - Folate may correct anemia but does NOT correct neurologic deficits from B12 deficiency - Always evaluate the cause of deficiency (malabsorption, diet, and related factors)
INDICATION: Vitamin B12 deficiency • Megaloblastic anemia • Neurologic deficiency states
Primary
Secondary
STANDARD (ADULT PO)
IM loading phase followed by maintenance; oral therapy may be used in selected patients
ADULT DOSE
STANDARD (ADULT): - IM loading phase -> maintenance dosing - Oral therapy may be used in selected cases
PEDIATRIC DOSE
Protocol-based
MAX DOSE
Not typically dose-limited in deficiency correction
Practical Note
- IM is preferred in severe deficiency or neurologic symptoms - Continue long-term therapy when the underlying cause persists
Clinical warnings
Adverse effects
Pediatrics
Protocol-based
Pregnancy
Malabsorption states: IM preferred (e.g., pernicious anemia) Pregnancy/
Lactation
Use when deficiency is confirmed and manage per protocol.
Renal impairment
No routine renal-specific adjustment in deficiency correction; follow protocol-based care where relevant.
Hepatic impairment
No routine hepatic-specific adjustment in deficiency correction.
Elderly
Higher risk of deficiency; monitor hematologic and neurologic response.
- IM injections for deficiency correction - Oral therapy in selected patients - Long-term therapy may be required
Clinical Picture
Minimal toxicity
Immediate Actions
Supportive care
Antidote
None
Decontamination
Supportive care as clinically indicated
Escalation
Escalate if an alternative diagnosis or severe reaction is suspected
Common mistakes, resistance logic, and bedside traps
Pharmacy Tool
solution · oral
Pharmacist verification beta
Preparation formulas are currently in pharmacist verification beta and must be validated against institutional protocols before use.
Acknowledge the statements above to unlock volume scaling and ingredient quantities.
- Oral absorption depends on intrinsic factor
- Essential for DNA synthesis and neurologic function
Saudi Arabia
Neurobion, Vitamin B12
Global
Cyanocobalamin, (placeholder — verify local formulation)
Common trade names are curated examples only — formulations and availability vary. Verify the exact product name with your local pharmacy and national regulator before prescribing or dispensing.
Global data (no country-specific data available)
Saudi Arabia
International